Caveolins and Caveolae
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- ASIN : 1461412218
- Publisher : Springer-Verlag New York Inc.; 2012th edition (30 January 2012)
- Language : English
- Hardcover : 184 pages
- ISBN-10 : 9781461412212
- ISBN-13 : 978-1461412212
- Item Weight : 567 g
- Dimensions : 19.05 x 1.91 x 26.67 cm
- Country of Origin : India
Description
Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.
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